TSSP1 - DrugMatrix
DrugMatrix, produced by the U.S. National Toxicology Program, is a molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in which rats or primary rat hepatocytes were systematically treated with therapeutic, industrial, ... [more] TOXsIgN May 11, 2020, 12:24 p.m.

TSSP2 - Open TG-GATEs
Open TG-GATEs is a toxicogenomics database open to the public for researchers to utilize research results of TGP and TGP2, and releases the data of 170 compounds stored in TG-GATEs. In Open TG-GATEs, it is possible to search toxicogenomics data by compound name or pathological finding. It is also possible ... [more] TOXsIgN May 11, 2020, 12:24 p.m.

TSSP3 - Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure
Among etiological factors of non-alcoholic fatty liver disease (NAFLD), a worldwide epidemic, environmental contaminants have gained importance. Among them, benzo[a]pyrene (B[a]P), a potent environmental carcinogen, in combination with ethanol, was shown to induce the transition of steatosis toward a steatohepatitis—like state both in vitro and in vivo. However, underlying mechanisms ... [more] / May 4, 2021, 10:45 a.m.

TSSP4 - CMap – carcinogenome project
The Connectivity Map, or CMap, is a resource that uses transcriptional expression data to probe relationships between diseases, cell physiology, and therapeutics. The changes in gene expression, or “signatures,” that arise from a disease, genetic perturbation (knockdown or overexpression of a gene) or treatment with a small molecule are compared ... [more] tdarde Jan. 27, 2022, 9:27 a.m.

TSSP5 - CMap – NLT_CALIB
The Connectivity Map, or CMap, is a resource that uses transcriptional expression data to probe relationships between diseases, cell physiology, and therapeutics. The changes in gene expression, or “signatures,” that arise from a disease, genetic perturbation (knockdown or overexpression of a gene) or treatment with a small molecule are compared ... [more] tdarde Dec. 16, 2022, 1:21 p.m.

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TSP736 - Triazole Antifungal Toxicogenomics: GeneLogic_Triazoles
Public Interventional

The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP737 - Triazole Antifungal Toxicogenomics: Iconix3_Triazoles
Public Interventional

The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP738 - Triazole Antifungal Toxicogenomics: rat_repro_Liver
Public Interventional

The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP739 - Triazole Antifungal Toxicogenomics: rat_repro_Testis
Public Interventional

The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP740 - Genetical toxicogenomics of lead treatment
Public Interventional

75 Diosophilia Roo lines, recominant inbred lines, were raised to adulthood either on conventional diet or diet supplemented with lead acetate. Whole flies were used for RNA extraction. RNA was ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.