TSSP1 - DrugMatrix
DrugMatrix, produced by the U.S. National Toxicology Program, is a molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in which rats or primary rat hepatocytes were systematically treated with therapeutic, industrial, ... [more] TOXsIgN May 11, 2020, 12:24 p.m.

TSSP2 - Open TG-GATEs
Open TG-GATEs is a toxicogenomics database open to the public for researchers to utilize research results of TGP and TGP2, and releases the data of 170 compounds stored in TG-GATEs. In Open TG-GATEs, it is possible to search toxicogenomics data by compound name or pathological finding. It is also possible ... [more] TOXsIgN May 11, 2020, 12:24 p.m.

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TSP741 - Toxicogenomic Comparison of TCDD and PCB 126 Responsiveness in Primary Human Hepatocytes
Public

Toxicogenomics has great potential for enhancing our understanding of environmental chemical toxicity, hopefully leading to better-informed human health risk assessments. This study employed toxicogenomic technology to reveal species differences in ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP742 - Toxicogenomic Comparison of TCDD and PCB 126 Responsiveness in Primary Rat Hepatocytes
Public

Toxicogenomics has great potential for enhancing our understanding of environmental chemical toxicity, hopefully leading to better-informed human health risk assessments. This study employed toxicogenomic technology to reveal species differences in ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP743 - Pathways identified by toxicogenomics analysis reveal the size and dose independency of silica particles-induced toxicity in mice.
Public

Understanding the interactions of nanostructures with biological systems is essential to nanotoxicological research. Using a microarray-based toxicogenomics approach at early stage, this study investigated the relationship between particle size and ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP744 - Gene expression profiles for onset and progression of Cyclosporin A-induced cholestasis in C57BL/6 mice
Public

Mechanism-based toxicogenomics (tgx) is used as a tool to identify markers reflective of the onset and progression of cholestasis in C57BL/6 mice using Cyclosporin A (CsA) as a model compound. ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP745 - Analyses of transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models
Public

For assessing the cancer-causing potential for humans of a chemical compound, the conventional approach is the use of the 2-year rodent carcinogenicity bioassay, thus alternatives such as in vitro toxicogenomics ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSA1 - DrugMatrix - Toxicogenomic signatures of Liver after exposure to nitrazepam (310 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA2 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA3 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 1 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA4 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA5 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSS1 - DrugMatrix - Toxicogenomic signatures of Liver after exposure to nitrazepam (310 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / Nitrazepam Male Adulthood 4 20

TSS2 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / 4-nonylphenol Male Adulthood 9 2

TSS3 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 1 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / 4-nonylphenol Male Adulthood 0 0

TSS4 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / Oxybutynin Male Adulthood 33 33

TSS5 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / Oxybutynin Male Adulthood 0 0