TSSP1 - DrugMatrix
DrugMatrix, produced by the U.S. National Toxicology Program, is a molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in which rats or primary rat hepatocytes were systematically treated with therapeutic, industrial, ... [more] TOXsIgN May 11, 2020, 12:24 p.m.

TSSP2 - Open TG-GATEs
Open TG-GATEs is a toxicogenomics database open to the public for researchers to utilize research results of TGP and TGP2, and releases the data of 170 compounds stored in TG-GATEs. In Open TG-GATEs, it is possible to search toxicogenomics data by compound name or pathological finding. It is also possible ... [more] TOXsIgN May 11, 2020, 12:24 p.m.

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TSP751 - Optimization of a toxicogenomics-based comparison approach to categorize chemicals based on their modes of action
Public

The current test strategy for carcinogenicity consists initially of in vivo and in vitro genotoxicity tests. Non-genotoxic carcinogens do not directly induce DNA damage and, as such, go undetected under ...

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TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP752 - Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (mRNA)
Public

The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo ...

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TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP753 - Toxicogenomics on mice liver of coumarins from Calophyllum brasiliense
Public

A toxicogenomic analysis from liver of different pharmacological active coumarins (mammea A/BA+A/BB 3:1 and soulatrolide ) was performed on mice treated (20mg/kg/daily) for a whole week to evaluate if such ...

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TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP754 - Toxicogenomic Characterization of Molecular Mechanisms Contributing to Chlorpyrifos Neurotoxicity in Adult Male Rats [microarray]
Public

Chlorpyrifos (CPF) is an organophosphorus pesticide (OP), and one of the most widely used pesticides in the world. Metabolites of CPF and other OPs continue to be identified in the ...

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TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP758 - Genome-wide transcriptional and functional analysis of human T lymphocytes exposed to benzo[a]pyrene
Public

Polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P), are widely distributed carcinogenic and immunotoxic environmental contaminants, known to affect T lymphocytes. Despite extensive studies conducted, the molecular targets and pathways ...

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/ Jan. 28, 2020, 9:53 a.m.

TSA1 - DrugMatrix - Toxicogenomic signatures of Liver after exposure to nitrazepam (310 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA2 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA3 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 1 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA4 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA5 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSS1 - DrugMatrix - Toxicogenomic signatures of Liver after exposure to nitrazepam (310 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / Nitrazepam Male Adulthood 4 20

TSS2 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / 4-nonylphenol Male Adulthood 9 2

TSS3 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 1 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / 4-nonylphenol Male Adulthood 0 0

TSS4 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / Oxybutynin Male Adulthood 33 33

TSS5 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / Oxybutynin Male Adulthood 0 0