TSSP1 - DrugMatrix
DrugMatrix, produced by the U.S. National Toxicology Program, is a molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in which rats or primary rat hepatocytes were systematically treated with therapeutic, industrial, ... [more] TOXsIgN May 11, 2020, 12:24 p.m.

TSSP2 - Open TG-GATEs
Open TG-GATEs is a toxicogenomics database open to the public for researchers to utilize research results of TGP and TGP2, and releases the data of 170 compounds stored in TG-GATEs. In Open TG-GATEs, it is possible to search toxicogenomics data by compound name or pathological finding. It is also possible ... [more] TOXsIgN May 11, 2020, 12:24 p.m.

TSSP3 - Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure
Among etiological factors of non-alcoholic fatty liver disease (NAFLD), a worldwide epidemic, environmental contaminants have gained importance. Among them, benzo[a]pyrene (B[a]P), a potent environmental carcinogen, in combination with ethanol, was shown to induce the transition of steatosis toward a steatohepatitis—like state both in vitro and in vivo. However, underlying mechanisms ... [more] / May 4, 2021, 10:45 a.m.

TSSP4 - CMap – carcinogenome project
The Connectivity Map, or CMap, is a resource that uses transcriptional expression data to probe relationships between diseases, cell physiology, and therapeutics. The changes in gene expression, or “signatures,” that arise from a disease, genetic perturbation (knockdown or overexpression of a gene) or treatment with a small molecule are compared ... [more] tdarde Jan. 27, 2022, 9:27 a.m.

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TSP1260 - CMap - carcinogenome project: Toxicogenomic signatures after exposure to procarbazine
Public

In the chemical selection process, we prioritized chemicals with long-term rodent liver carcinogenicity annotation for inclusion in this experiment. Long-term carcinogenicity annotations were derived from the Carcinogenic Potency Database (CPDB) ...

[more]
tdarde Jan. 27, 2022, 4:27 p.m.

TSP1261 - CMap - carcinogenome project: Toxicogenomic signatures after exposure to o-anisidine.hcl
Public

In the chemical selection process, we prioritized chemicals with long-term rodent liver carcinogenicity annotation for inclusion in this experiment. Long-term carcinogenicity annotations were derived from the Carcinogenic Potency Database (CPDB) ...

[more]
tdarde Jan. 27, 2022, 4:27 p.m.

TSP1262 - CMap - carcinogenome project: Toxicogenomic signatures after exposure to cyclophosphamide
Public

In the chemical selection process, we prioritized chemicals with long-term rodent liver carcinogenicity annotation for inclusion in this experiment. Long-term carcinogenicity annotations were derived from the Carcinogenic Potency Database (CPDB) ...

[more]
tdarde Jan. 27, 2022, 4:27 p.m.

TSP1263 - CMap - carcinogenome project: Toxicogenomic signatures after exposure to ifosfamide
Public

In the chemical selection process, we prioritized chemicals with long-term rodent liver carcinogenicity annotation for inclusion in this experiment. Long-term carcinogenicity annotations were derived from the Carcinogenic Potency Database (CPDB) ...

[more]
tdarde Jan. 27, 2022, 4:27 p.m.

TSP1264 - CMap - carcinogenome project: Toxicogenomic signatures after exposure to benzo[k]fluoranthene
Public

In the chemical selection process, we prioritized chemicals with long-term rodent liver carcinogenicity annotation for inclusion in this experiment. Long-term carcinogenicity annotations were derived from the Carcinogenic Potency Database (CPDB) ...

[more]
tdarde Jan. 27, 2022, 4:27 p.m.

TSA1 - DrugMatrix - Toxicogenomic signatures of Liver after exposure to nitrazepam (310 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA2 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA3 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 1 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA4 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA5 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSS1 - DrugMatrix - Toxicogenomic signatures of Liver after exposure to nitrazepam (310 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / Nitrazepam Male Adulthood 4 20

TSS2 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / 4-nonylphenol Male Adulthood 9 2

TSS3 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 1 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / 4-nonylphenol Male Adulthood 0 0

TSS4 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / Oxybutynin Male Adulthood 33 33

TSS5 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / Oxybutynin Male Adulthood 0 0