TSSP1 - DrugMatrix
DrugMatrix, produced by the U.S. National Toxicology Program, is a molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in which rats or primary rat hepatocytes were systematically treated with therapeutic, industrial, ... [more] TOXsIgN May 11, 2020, 12:24 p.m.

TSSP2 - Open TG-GATEs
Open TG-GATEs is a toxicogenomics database open to the public for researchers to utilize research results of TGP and TGP2, and releases the data of 170 compounds stored in TG-GATEs. In Open TG-GATEs, it is possible to search toxicogenomics data by compound name or pathological finding. It is also possible ... [more] TOXsIgN May 11, 2020, 12:24 p.m.

TSSP3 - Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure
Among etiological factors of non-alcoholic fatty liver disease (NAFLD), a worldwide epidemic, environmental contaminants have gained importance. Among them, benzo[a]pyrene (B[a]P), a potent environmental carcinogen, in combination with ethanol, was shown to induce the transition of steatosis toward a steatohepatitis—like state both in vitro and in vivo. However, underlying mechanisms ... [more] / May 4, 2021, 10:45 a.m.

TSSP4 - CMap – carcinogenome project
The Connectivity Map, or CMap, is a resource that uses transcriptional expression data to probe relationships between diseases, cell physiology, and therapeutics. The changes in gene expression, or “signatures,” that arise from a disease, genetic perturbation (knockdown or overexpression of a gene) or treatment with a small molecule are compared ... [more] tdarde Jan. 27, 2022, 9:27 a.m.

TSSP5 - CMap – NLT_CALIB
The Connectivity Map, or CMap, is a resource that uses transcriptional expression data to probe relationships between diseases, cell physiology, and therapeutics. The changes in gene expression, or “signatures,” that arise from a disease, genetic perturbation (knockdown or overexpression of a gene) or treatment with a small molecule are compared ... [more] tdarde Dec. 16, 2022, 1:21 p.m.

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TSP1 - DrugMatrix - Toxicogenomic signatures after exposure to nitrazepam in the rat
Public Interventional

DrugMatrix is the scientific communities' largest molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP2 - DrugMatrix - Toxicogenomic signatures after exposure to 4-nonylphenol in the rat
Public Interventional

DrugMatrix is the scientific communities' largest molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP3 - DrugMatrix - Toxicogenomic signatures after exposure to oxybutynin in the rat
Public Interventional

DrugMatrix is the scientific communities' largest molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP4 - DrugMatrix - Toxicogenomic signatures after exposure to n-nitrosodimethylamine in the rat
Public Interventional

DrugMatrix is the scientific communities' largest molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP5 - DrugMatrix - Toxicogenomic signatures after exposure to pirinixic acid in the rat
Public Interventional

DrugMatrix is the scientific communities' largest molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.