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TSS13286 - CMap - carcinogenome project: Toxicogenomic signatures in the human cell line MCF10A.WT.HP after exposure to benzo[k]fluoranthene 33.66 µM PublicGenomics
For each perturbation and landmark gene, we computed the change in gene expression following the perturbation using a moderated z-score procedure as described in the CMap–L1000 workflow. Differential expression values were calculated as moderated z-scores for each landmark gene and each unique perturbation (chemical and dose combination) perturbation, collapsed to a single value across replicates. (Li et al. 2019; Subramanian et al. 2017). /n When absolute z-scores are superior to 1.96, genes are considered as differentially expressed.