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TSS8495 - Toxicogenomic signature of primary T lymphocytes exposed to B[a]P PublicInterventional
The statistical filtration of the genes differentially expressed between CTR and B[a]P-treated samples was performed using the Annotation, Mapping, Expression and Network suite of tools (Chalmel and Primig, 2008). Briefly, we first filtered genes with at least one signal above the background expression cutoff (> 0.0) and with a minimal variation of 10% between both experimental conditions as determined by the inflection point of the fold-change curve. Finally, a paired Student's t test (p = 0.05) was used to identify significantly differentially expressed genes which were further classified into two expression patterns: up-regulated and down-regulated genes after B[a]P exposure.
