The team behind TOXsIgN has invested considerable time, resources, and effort into collecting, curating, processing, developing, and maintaining this web resource.
Please follow the citation guidelines if you are using it.
Please follow the citation guidelines if you are using it.
TSS8507 - Ctrl_Male Vs Exposed_Male
Public
Interventional
Summary
| Organism |
|
Rattus norvegicus |
|---|
Characteristics
| Experimental type | Na |
|---|---|
| Sex | Male |
| Generation | F1 |
| Developmental stage | Fetal |
Overview
No up/down regulated genes
Genomic signature information
| Technology used | Array |
|---|---|
| Platform | GPL23953 |
Statistical information
| Control samples | 4 |
|---|---|
| Treated samples | 5 |
| Pvalue Cutoff | 0.05 |
| FC Cutoff | None |
| Statistical processing | Data analysis was performed using and the AMEN suite of tools (Chalmel & Primig, 2008). Briefly, genes showing a signal higher than a given background cutoff (median of the normalized dataset) and at least a 1.5-fold change in at least one pairwise comparison were selected. To define a set of 364 genes displaying significant statistical changes across comparisons, the empirical Bayes moderated t-statistics was performed using the limma package (F-value adjusted using the Benjamini & Hochberg (BH) False Discovery Rate approach, p =< 0.05) . The resulting genes were then partitioned into two broad expression clusters (termed C1 and C2) using the k-means algorithm. |
Associated Factors
Chemical factor n° 1
| Chemical | finasteride |
|---|---|
| Route | Oral gavage |
| Vehicule | Corn oil |
| Dose | 10.0 mg/kg |
| Exposure time | 336.0 hours |
| Exposure frequencies | 10 mg/kg bw/day |
No biological subfactors linked to this factor
No physical subfactors linked to this factor