TSSP1 - DrugMatrix
DrugMatrix, produced by the U.S. National Toxicology Program, is a molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in which rats or primary rat hepatocytes were systematically treated with therapeutic, industrial, ... [more] TOXsIgN May 11, 2020, 12:24 p.m.

TSSP2 - Open TG-GATEs
Open TG-GATEs is a toxicogenomics database open to the public for researchers to utilize research results of TGP and TGP2, and releases the data of 170 compounds stored in TG-GATEs. In Open TG-GATEs, it is possible to search toxicogenomics data by compound name or pathological finding. It is also possible ... [more] TOXsIgN May 11, 2020, 12:24 p.m.

There are no superprojects yet.

TSP746 - Analyses of transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models
Public

For assessing the cancer-causing potential for humans of a chemical compound, the conventional approach is the use of the 2-year rodent carcinogenicity bioassay, thus alternatives such as in vitro toxicogenomics ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP747 - Gene expression profiles of amiodarone, valproic acid, and tetracycline induced steatosis in C57BL/6 mice
Public

Toxicogenomics (tgx) is used as a tool to identify mechanisms and markers of steatosis in C57BL/6 mice treated by oral gavage using amiodarone (AMD), valproic acid (VPA), and tetracycline (TET). ...

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TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP748 - Evaluation of the robustness of classification of carcinogen-modified transcriptomic responses in HepaRG cells and the interlaboratory reproducibility of the model
Public

Efforts to develop alternatives which can at least partially replace some of the currently used in vivo tests are ongoing. The recently ended FP6 European project carcinoGENOMICS had the goal ...

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TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP749 - Gene expression profiles of acetaminophen, isoniazid, and paraquat treated C57BL/6 mice
Public

Toxicogenomics (tgx) is used as a tool to identify mechanisms and markers of necrosis in C57BL/6 mice treated by oral gavage using acetaminophen (APAP), isoniazid (INZ), and paraquat (PQ). Critical ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSP750 - Cross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (mRNA)
Public

In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. ...

[more]
TOXsIgN Jan. 28, 2020, 9:53 a.m.

TSA1 - DrugMatrix - Toxicogenomic signatures of Liver after exposure to nitrazepam (310 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA2 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA3 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 1 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA4 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSA5 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Sex Stage
Public / / Male Adulthood
TSS1 - DrugMatrix - Toxicogenomic signatures of Liver after exposure to nitrazepam (310 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / Nitrazepam Male Adulthood 4 20

TSS2 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / 4-nonylphenol Male Adulthood 9 2

TSS3 - DrugMatrix - Toxicogenomic signatures of Kidney after exposure to 4-nonylphenol (200 mg/kg, 1 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / 4-nonylphenol Male Adulthood 0 0

TSS4 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 5 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / Oxybutynin Male Adulthood 33 33

TSS5 - DrugMatrix - Toxicogenomic signatures of Heart after exposure to oxybutynin (230 mg/kg, 3 days) in the rat
Organism Tissue Cell Cell line Chemical Sex Stage Up genes Down genes
Public Genomics / / Oxybutynin Male Adulthood 0 0